In depends on the business and the position.
In the bar business, I would rather work for a larger, multi-location business. They seem to be better run with less “the family comes first” attitudes. Small “family” bars also tend to not obey all of the laws, allow drinking by employees, run out of stock, not be as clean, because they fly under the radar of the law.
In production work, I would rather work for a smaller family run business. They pay better, often supply better benefits, and honestly appreciate the employees more, but you work more hours.